Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids.J Am Chem Soc. 2022 May 18;144(19):8480-8486. doi: 10.1021/jacs.2c02323. Epub 2022 Apr 21.PMID: 35446570
Publications
Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands.Nichols AL, Blumenfeld Z, Fan C, Luebbert L, Blom AEM, Cohen BN, Marvin JS, Borden PM, Kim CH, Muthusamy AK, Shivange AV, Knox HJ, Campello HR, Wang JH, Dougherty DA, Looger LL, Gallagher T, Rees DC, Lester HA.Elife. 2022 Jan 4;11:e74648. doi: 10.7554/eLife.74648.PMID: 34982029 Free PMC article.
A sequence-based method for predicting extant fold switchers that undergo α-helix ↔ β-strand transitions.Mishra S, Looger LL, Porter LL.Biopolymers. 2021 Oct;112(10):e23471. doi: 10.1002/bip.23471. Epub 2021 Sep 9.PMID: 34498740
In vivo glucose imaging in multiple model organisms with an engineered single-wavelength sensor.Keller JP, Marvin JS, Lacin H, Lemon WC, Shea J, Kim S, Lee RT, Koyama M, Keller PJ, Looger LL.Cell Rep. 2021 Jun 22;35(12):109284. doi: 10.1016/j.celrep.2021.109284.PMID: 34161775 Free article.
The functional organization of excitatory synaptic input to place cells.Adoff MD, Climer JR, Davoudi H, Marvin JS, Looger LL, Dombeck DA.Nat Commun. 2021 Jun 11;12(1):3558. doi: 10.1038/s41467-021-23829-y.PMID: 34117238 Free PMC article.
Lupus Susceptibility Region Containing CDKN1B rs34330 Mechanistically Influences Expression and Function of Multiple Target Genes, Also Linked to Proliferation and Apoptosis.Singh B, Maiti GP, Zhou X, Fazel-Najafabadi M, Bae SC, Sun C, Terao C, Okada Y, Heng Chua K, Kochi Y, Guthridge JM, Zhang H, Weirauch M, James JA, Harley JB, Varshney GK, Looger LL, Nath SK.Arthritis Rheumatol. 2021 Dec;73(12):2303-2313. doi: 10.1002/art.41799. Epub 2021 Oct 29.PMID: 33982894
Evaluation of multi-color genetically encoded Ca2+ indicators in filamentous fungi.Kim HS, Kim JE, Hwangbo A, Akerboom J, Looger LL, Duncan R, Son H, Czymmek KJ, Kang S.Fungal Genet Biol. 2021 Apr;149:103540. doi: 10.1016/j.fgb.2021.103540. Epub 2021 Feb 16.PMID: 33607281 Free article.
A high-throughput predictive method for sequence-similar fold switchers.Kim AK, Looger LL, Porter LL.Biopolymers. 2021 Oct;112(10):e23416. doi: 10.1002/bip.23416. Epub 2021 Jan 19.PMID: 33462801 Free PMC article.
Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L.Cell. 2020 Dec 23;183(7):1986-2002.e26. doi: 10.1016/j.cell.2020.11.040. Epub 2020 Dec 16.PMID: 33333022 Free PMC article.
Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells.Benedetti L, Marvin JS, Falahati H, Guillén-Samander A, Looger LL, De Camilli P.Elife. 2020 Nov 11;9:e63230. doi: 10.7554/eLife.63230.PMID: 33174843 Free PMC article.
A general approach to engineer positive-going eFRET voltage indicators.Abdelfattah AS, Valenti R, Zheng J, Wong A; GENIE Project Team, Podgorski K, Koyama M, Kim DS, Schreiter ER.Nat Commun. 2020 Jul 10;11(1):3444. doi: 10.1038/s41467-020-17322-1.PMID: 32651384 Free PMC article.
jYCaMP: an optimized calcium indicator for two-photon imaging at fiber laser wavelengths.Mohr MA, Bushey D, Aggarwal A, Marvin JS, Kim JJ, Marquez EJ, Liang Y, Patel R, Macklin JJ, Lee CY, Tsang A, Tsegaye G, Ahrens AM, Chen JL, Kim DS, Wong AM, Looger LL, Schreiter ER, Podgorski K.Nat Methods. 2020 Jul;17(7):694-697. doi: 10.1038/s41592-020-0835-7. Epub 2020 May 25.PMID: 32451475 Free PMC article.
Nanoscopic Visualization of Restricted Nonvolume Cholinergic and Monoaminergic Transmission with Genetically Encoded Sensors.Zhu PK, Zheng WS, Zhang P, Jing M, Borden PM, Ali F, Guo K, Feng J, Marvin JS, Wang Y, Wan J, Gan L, Kwan AC, Lin L, Looger LL, Li Y, Zhang Y.Nano Lett. 2020 Jun 10;20(6):4073-4083. doi: 10.1021/acs.nanolett.9b04877. Epub 2020 May 12.PMID: 32396366 Free PMC article.
Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b.Weber C, Zhou Y, Lee JG, Looger LL, Qian G, Ge C, Capel B.Science. 2020 Apr 17;368(6488):303-306. doi: 10.1126/science.aaz4165.PMID: 32299951
The neuropeptide Drosulfakinin regulates social isolation-induced aggression in Drosophila.Agrawal P, Kao D, Chung P, Looger LL.J Exp Biol. 2020 Jan 29;223(Pt 2):jeb207407. doi: 10.1242/jeb.207407.PMID: 31900346 Free PMC article.
Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum.Bera K, Kamajaya A, Shivange AV, Muthusamy AK, Nichols AL, Borden PM, Grant S, Jeon J, Lin E, Bishara I, Chin TM, Cohen BN, Kim CH, Unger EK, Tian L, Marvin JS, Looger LL, Lester HA.Front Cell Neurosci. 2019 Nov 12;13:499. doi: 10.3389/fncel.2019.00499. eCollection 2019.PMID: 31798415 Free PMC article.
Single-Cell Reconstruction of Emerging Population Activity in an Entire Developing Circuit.Wan Y, Wei Z, Looger LL, Koyama M, Druckmann S, Keller PJ.Cell. 2019 Oct 3;179(2):355-372.e23. doi: 10.1016/j.cell.2019.08.039. Epub 2019 Sep 26.PMID: 31564455 Free PMC article.
Voices in methods development.Anikeeva P, Boyden E, Brangwynne C, Cissé II, Fiehn O, Fromme P, Gingras AC, Greene CS, Heard E, Hell SW, Hillman E, Jensen GJ, Karchin R, Kiessling LL, Kleinstiver BP, Knight R, Kukura P, Lancaster MA, Loman N, Looger L, Lundberg E, Luo Q, Miyawaki A, Myers EW Jr, Nolan GP, Picotti P, Reik W, Sauer M, Shalek AK, Shendure J, Slavov N, Tanay A, Troyanskaya O, van Valen D, Wang HW, Yi C, Yin P, Zernicka-Goetz M, Zhuang X.Nat Methods. 2019 Oct;16(10):945-951. doi: 10.1038/s41592-019-0585-6.PMID: 31562479 Free PMC article.
Author Correction: Kilohertz frame-rate two-photon tomography.Kazemipour A, Novak O, Flickinger D, Marvin JS, Abdelfattah AS, King J, Borden PM, Kim JJ, Al-Abdullatif SH, Deal PE, Miller EW, Schreiter ER, Druckmann S, Svoboda K, Looger LL, Podgorski K.Nat Methods. 2019 Sep;16(9):932. doi: 10.1038/s41592-019-0545-1.PMID: 31388143
Kilohertz frame-rate two-photon tomography.Kazemipour A, Novak O, Flickinger D, Marvin JS, Abdelfattah AS, King J, Borden PM, Kim JJ, Al-Abdullatif SH, Deal PE, Miller EW, Schreiter ER, Druckmann S, Svoboda K, Looger LL, Podgorski K.Nat Methods. 2019 Aug;16(8):778-786. doi: 10.1038/s41592-019-0493-9. Epub 2019 Jul 29.PMID: 31363222 Free PMC article.
A genetically encoded fluorescent sensor for in vivo imaging of GABA.Marvin JS, Shimoda Y, Magloire V, Leite M, Kawashima T, Jensen TP, Kolb I, Knott EL, Novak O, Podgorski K, Leidenheimer NJ, Rusakov DA, Ahrens MB, Kullmann DM, Looger LL.Nat Methods. 2019 Aug;16(8):763-770. doi: 10.1038/s41592-019-0471-2. Epub 2019 Jul 15.PMID: 31308547
Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior.Mu Y, Bennett DV, Rubinov M, Narayan S, Yang CT, Tanimoto M, Mensh BD, Looger LL, Ahrens MB.Cell. 2019 Jun 27;178(1):27-43.e19. doi: 10.1016/j.cell.2019.05.050. Epub 2019 Jun 20.PMID: 31230713
High-performance calcium sensors for imaging activity in neuronal populations and microcompartments.Dana H, Sun Y, Mohar B, Hulse BK, Kerlin AM, Hasseman JP, Tsegaye G, Tsang A, Wong A, Patel R, Macklin JJ, Chen Y, Konnerth A, Jayaraman V, Looger LL, Schreiter ER, Svoboda K, Kim DS.Nat Methods. 2019 Jul;16(7):649-657. doi: 10.1038/s41592-019-0435-6. Epub 2019 Jun 17.PMID: 31209382
Mechanistic Characterization of RASGRP1 Variants Identifies an hnRNP-K-Regulated Transcriptional Enhancer Contributing to SLE Susceptibility.Molineros JE, Singh B, Terao C, Okada Y, Kaplan J, McDaniel B, Akizuki S, Sun C, Webb CF, Looger LL, Nath SK.Front Immunol. 2019 May 20;10:1066. doi: 10.3389/fimmu.2019.01066. eCollection 2019.PMID: 31164884 Free PMC article.
Inaccurate secondary structure predictions often indicate protein fold switching.Mishra S, Looger LL, Porter LL.Protein Sci. 2019 Aug;28(8):1487-1493. doi: 10.1002/pro.3664. Epub 2019 Jun 17.PMID: 31148305 Free PMC article.
Quantitative in vivo imaging of neuronal glucose concentrations with a genetically encoded fluorescence lifetime sensor.Díaz-García CM, Lahmann C, Martínez-François JR, Li B, Koveal D, Nathwani N, Rahman M, Keller JP, Marvin JS, Looger LL, Yellen G.J Neurosci Res. 2019 Aug;97(8):946-960. doi: 10.1002/jnr.24433. Epub 2019 May 20.PMID: 31106909 Free PMC article.
Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians.Molineros JE, Looger LL, Kim K, Okada Y, Terao C, Sun C, Zhou XJ, Raj P, Kochi Y, Suzuki A, Akizuki S, Nakabo S, Bang SY, Lee HS, Kang YM, Suh CH, Chung WT, Park YB, Choe JY, Shim SC, Lee SS, Zuo X, Yamamoto K, Li QZ, Shen N, Porter LL, Harley JB, Chua KH, Zhang H, Wakeland EK, Tsao BP, Bae SC, Nath SK.PLoS Genet. 2019 Apr 25;15(4):e1008092. doi: 10.1371/journal.pgen.1008092. eCollection 2019 Apr.PMID: 31022184 Free PMC article.
Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ.Jensen TP, Zheng K, Cole N, Marvin JS, Looger LL, Rusakov DA.Nat Commun. 2019 Mar 29;10(1):1414. doi: 10.1038/s41467-019-09216-8.PMID: 30926781 Free PMC article.
Author Correction: Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR.Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JA, Schoch S, Quiroz FJU, Rebola N, Bao H, Little JP, Tkachuk AN, Cai E, Hantman AW, Wang SS, DePiero VJ, Borghuis BG, Chapman ER, Dietrich D, DiGregorio DA, Fitzpatrick D, Looger LL.Nat Methods. 2019 Apr;16(4):351. doi: 10.1038/s41592-019-0363-5.PMID: 30820033
A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP.Lobas MA, Tao R, Nagai J, Kronschläger MT, Borden PM, Marvin JS, Looger LL, Khakh BS.Nat Commun. 2019 Feb 12;10(1):711. doi: 10.1038/s41467-019-08441-5.PMID: 30755613 Free PMC article.
Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors.Shivange AV, Borden PM, Muthusamy AK, Nichols AL, Bera K, Bao H, Bishara I, Jeon J, Mulcahy MJ, Cohen B, O’Riordan SL, Kim C, Dougherty DA, Chapman ER, Marvin JS, Looger LL, Lester HA.J Gen Physiol. 2019 Jun 3;151(6):738-757. doi: 10.1085/jgp.201812201. Epub 2019 Feb 4.PMID: 30718376 Free PMC article.
Publisher Correction: Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR.Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JA, Schoch S, Urra Quiroz FJ, Rebola N, Bao H, Little JP, Tkachuk AN, Cai E, Hantman AW, Wang SS, DePiero VJ, Borghuis BG, Chapman ER, Dietrich D, DiGregorio DA, Fitzpatrick D, Looger LL.Nat Methods. 2019 Feb;16(2):206. doi: 10.1038/s41592-018-0300-z.PMID: 30602783
Distinct descending motor cortex pathways and their roles in movement.Economo MN, Viswanathan S, Tasic B, Bas E, Winnubst J, Menon V, Graybuck LT, Nguyen TN, Smith KA, Yao Z, Wang L, Gerfen CR, Chandrashekar J, Zeng H, Looger LL, Svoboda K.Nature. 2018 Nov;563(7729):79-84. doi: 10.1038/s41586-018-0642-9. Epub 2018 Oct 31.PMID: 30382200
Shared and distinct transcriptomic cell types across neocortical areas.Tasic B, Yao Z, Graybuck LT, Smith KA, Nguyen TN, Bertagnolli D, Goldy J, Garren E, Economo MN, Viswanathan S, Penn O, Bakken T, Menon V, Miller J, Fong O, Hirokawa KE, Lathia K, Rimorin C, Tieu M, Larsen R, Casper T, Barkan E, Kroll M, Parry S, Shapovalova NV, Hirschstein D, Pendergraft J, Sullivan HA, Kim TK, Szafer A, Dee N, Groblewski P, Wickersham I, Cetin A, Harris JA, Levi BP, Sunkin SM, Madisen L, Daigle TL, Looger L, Bernard A, Phillips J, Lein E, Hawrylycz M, Svoboda K, Jones AR, Koch C, Zeng H.Nature. 2018 Nov;563(7729):72-78. doi: 10.1038/s41586-018-0654-5. Epub 2018 Oct 31.PMID: 30382198 Free PMC article.
Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR.Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JA, Schoch S, Quiroz FJU, Rebola N, Bao H, Little JP, Tkachuk AN, Cai E, Hantman AW, Wang SS, DePiero VJ, Borghuis BG, Chapman ER, Dietrich D, DiGregorio DA, Fitzpatrick D, Looger LL.Nat Methods. 2018 Nov;15(11):936-939. doi: 10.1038/s41592-018-0171-3. Epub 2018 Oct 30.PMID: 30377363 Free PMC article.
Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model.Mizuno GO, Wang Y, Shi G, Wang Y, Sun J, Papadopoulos S, Broussard GJ, Unger EK, Deng W, Weick J, Bhattacharyya A, Chen CY, Yu G, Looger LL, Tian L.Cell Rep. 2018 Jul 10;24(2):355-365. doi: 10.1016/j.celrep.2018.06.033.PMID: 29996097 Free PMC article.
Extant fold-switching proteins are widespread.Porter LL, Looger LL.Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):5968-5973. doi: 10.1073/pnas.1800168115. Epub 2018 May 21.PMID: 29784778 Free PMC article.
Functional Imaging and Optogenetics in Drosophila.Simpson JH, Looger LL.Genetics. 2018 Apr;208(4):1291-1309. doi: 10.1534/genetics.117.300228.PMID: 29618589 Free PMC article. Review.
Neural signatures of dynamic stimulus selection in Drosophila.Sun Y, Nern A, Franconville R, Dana H, Schreiter ER, Looger LL, Svoboda K, Kim DS, Hermundstad AM, Jayaraman V.Nat Neurosci. 2017 Aug;20(8):1104-1113. doi: 10.1038/nn.4581. Epub 2017 Jun 12.PMID: 28604683
Diverse protocols for correlative super-resolution fluorescence imaging and electron microscopy of chemically fixed samples.Kopek BG, Paez-Segala MG, Shtengel G, Sochacki KA, Sun MG, Wang Y, Xu CS, van Engelenburg SB, Taraska JW, Looger LL, Hess HF.Nat Protoc. 2017 May;12(5):916-946. doi: 10.1038/nprot.2017.017. Epub 2017 Apr 6.PMID: 28384138 Free PMC article.
Confirmation of five novel susceptibility loci for systemic lupus erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci.Molineros JE, Yang W, Zhou XJ, Sun C, Okada Y, Zhang H, Heng Chua K, Lau YL, Kochi Y, Suzuki A, Yamamoto K, Ma J, Bang SY, Lee HS, Kim K, Bae SC, Zhang H, Shen N, Looger LL, Nath SK.Hum Mol Genet. 2017 Mar 15;26(6):1205-1216. doi: 10.1093/hmg/ddx026.PMID: 28108556 Free PMC article.
All-optical functional synaptic connectivity mapping in acute brain slices using the calcium integrator CaMPARI.Zolnik TA, Sha F, Johenning FW, Schreiter ER, Looger LL, Larkum ME, Sachdev RN.J Physiol. 2017 Mar 1;595(5):1465-1477. doi: 10.1113/JP273116. Epub 2016 Dec 14.PMID: 27861906 Free PMC article.
A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons.Tervo DG, Hwang BY, Viswanathan S, Gaj T, Lavzin M, Ritola KD, Lindo S, Michael S, Kuleshova E, Ojala D, Huang CC, Gerfen CR, Schiller J, Dudman JT, Hantman AW, Looger LL, Schaffer DV, Karpova AY.Neuron. 2016 Oct 19;92(2):372-382. doi: 10.1016/j.neuron.2016.09.021. Epub 2016 Oct 6.PMID: 27720486 Free PMC article.
The Oscillating Stimulus Transporter Assay, OSTA: Quantitative Functional Imaging of Transporter Protein Activity in Time and Frequency Domains.Keller JP, Looger LL.Mol Cell. 2016 Oct 6;64(1):199-212. doi: 10.1016/j.molcel.2016.09.001.PMID: 27716484 Free article.
A timecourse analysis of systemic and gonadal effects of temperature on sexual development of the red-eared slider turtle Trachemys scripta elegans.Czerwinski M, Natarajan A, Barske L, Looger LL, Capel B.Dev Biol. 2016 Dec 1;420(1):166-177. doi: 10.1016/j.ydbio.2016.09.018. Epub 2016 Sep 23.PMID: 27671871 Free article.
Molecularly Defined Subplate Neurons Project Both to Thalamocortical Recipient Layers and Thalamus.Viswanathan S, Sheikh A, Looger LL, Kanold PO.Cereb Cortex. 2017 Oct 1;27(10):4759-4768. doi: 10.1093/cercor/bhw271.PMID: 27655928 Free PMC article.
Falling apart.Marvin JS, Looger LL.Elife. 2016 Jun 27;5:e18203. doi: 10.7554/eLife.18203.PMID: 27345573 Free PMC article.
Real-time quantification of single RNA translation dynamics in living cells.Morisaki T, Lyon K, DeLuca KF, DeLuca JG, English BP, Zhang Z, Lavis LD, Grimm JB, Viswanathan S, Looger LL, Lionnet T, Stasevich TJ.Science. 2016 Jun 17;352(6292):1425-9. doi: 10.1126/science.aaf0899. Epub 2016 May 5.PMID: 27313040
GFP-Aequorin Protein Sensor for Ex Vivo and In Vivo Imaging of Ca(2+) Dynamics in High-Ca(2+) Organelles.Navas-Navarro P, Rojo-Ruiz J, Rodriguez-Prados M, Ganfornina MD, Looger LL, Alonso MT, García-Sancho J.Cell Chem Biol. 2016 Jun 23;23(6):738-45. doi: 10.1016/j.chembiol.2016.05.010. Epub 2016 Jun 9.PMID: 27291400 Free article.
Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington’s Disease Model Mice.Jiang R, Diaz-Castro B, Looger LL, Khakh BS.J Neurosci. 2016 Mar 23;36(12):3453-70. doi: 10.1523/JNEUROSCI.3693-15.2016.PMID: 27013675 Free PMC article.
Sensitive red protein calcium indicators for imaging neural activity.Dana H, Mohar B, Sun Y, Narayan S, Gordus A, Hasseman JP, Tsegaye G, Holt GT, Hu A, Walpita D, Patel R, Macklin JJ, Bargmann CI, Ahrens MB, Schreiter ER, Jayaraman V, Looger LL, Svoboda K, Kim DS.Elife. 2016 Mar 24;5:e12727. doi: 10.7554/eLife.12727.PMID: 27011354 Free PMC article.
High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry.Sun C, Molineros JE, Looger LL, Zhou XJ, Kim K, Okada Y, Ma J, Qi YY, Kim-Howard X, Motghare P, Bhattarai K, Adler A, Bang SY, Lee HS, Kim TH, Kang YM, Suh CH, Chung WT, Park YB, Choe JY, Shim SC, Kochi Y, Suzuki A, Kubo M, Sumida T, Yamamoto K, Lee SS, Kim YJ, Han BG, Dozmorov M, Kaufman KM, Wren JD, Harley JB, Shen N, Chua KH, Zhang H, Bae SC, Nath SK.Nat Genet. 2016 Mar;48(3):323-30. doi: 10.1038/ng.3496. Epub 2016 Jan 25.PMID: 26808113 Free PMC article.
Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux.Beerman RW, Matty MA, Au GG, Looger LL, Choudhury KR, Keller PJ, Tobin DM.Cell Rep. 2015 Dec 15;13(10):2107-17. doi: 10.1016/j.celrep.2015.11.010. Epub 2015 Dec 7.PMID: 26673320 Free PMC article.
A Low Affinity GCaMP3 Variant (GCaMPer) for Imaging the Endoplasmic Reticulum Calcium Store.Henderson MJ, Baldwin HA, Werley CA, Boccardo S, Whitaker LR, Yan X, Holt GT, Schreiter ER, Looger LL, Cohen AE, Kim DS, Harvey BK.PLoS One. 2015 Oct 9;10(10):e0139273. doi: 10.1371/journal.pone.0139273. eCollection 2015.PMID: 26451944 Free PMC article.
Green-to-Red Photoconversion of GCaMP.Ai M, Mills H, Kanai M, Lai J, Deng J, Schreiter E, Looger L, Neubert T, Suh G.PLoS One. 2015 Sep 18;10(9):e0138127. doi: 10.1371/journal.pone.0138127. eCollection 2015.PMID: 26382605 Free PMC article.
High-performance probes for light and electron microscopy.Viswanathan S, Williams ME, Bloss EB, Stasevich TJ, Speer CM, Nern A, Pfeiffer BD, Hooks BM, Li WP, English BP, Tian T, Henry GL, Macklin JJ, Patel R, Gerfen CR, Zhuang X, Wang Y, Rubin GM, Looger LL.Nat Methods. 2015 Jun;12(6):568-76. doi: 10.1038/nmeth.3365. Epub 2015 Apr 27.PMID: 25915120 Free PMC article.
Dynamics of Ionic Shifts in Cortical Spreading Depression.Enger R, Tang W, Vindedal GF, Jensen V, Johannes Helm P, Sprengel R, Looger LL, Nagelhus EA.Cereb Cortex. 2015 Nov;25(11):4469-76. doi: 10.1093/cercor/bhv054. Epub 2015 Apr 2.PMID: 25840424 Free PMC article.
Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.Tang W, Szokol K, Jensen V, Enger R, Trivedi CA, Hvalby Ø, Helm PJ, Looger LL, Sprengel R, Nagelhus EA.J Neurosci. 2015 Feb 18;35(7):3016-21. doi: 10.1523/JNEUROSCI.3319-14.2015.PMID: 25698739 Free PMC article.
Neural circuits. Labeling of active neural circuits in vivo with designed calcium integrators.Fosque BF, Sun Y, Dana H, Yang CT, Ohyama T, Tadross MR, Patel R, Zlatic M, Kim DS, Ahrens MB, Jayaraman V, Looger LL, Schreiter ER.Science. 2015 Feb 13;347(6223):755-60. doi: 10.1126/science.1260922.PMID: 25678659
Fixation-resistant photoactivatable fluorescent proteins for CLEM.Paez-Segala MG, Sun MG, Shtengel G, Viswanathan S, Baird MA, Macklin JJ, Patel R, Allen JR, Howe ES, Piszczek G, Hess HF, Davidson MW, Wang Y, Looger LL.Nat Methods. 2015 Mar;12(3):215-8, 4 p following 218. doi: 10.1038/nmeth.3225. Epub 2015 Jan 12.PMID: 25581799 Free PMC article.
Thy1-GCaMP6 transgenic mice for neuronal population imaging in vivo.Dana H, Chen TW, Hu A, Shields BC, Guo C, Looger LL, Kim DS, Svoboda K.PLoS One. 2014 Sep 24;9(9):e108697. doi: 10.1371/journal.pone.0108697. eCollection 2014.PMID: 25250714 Free PMC article.
Integrated action of pheromone signals in promoting courtship behavior in male mice.Haga-Yamanaka S, Ma L, He J, Qiu Q, Lavis LD, Looger LL, Yu CR.Elife. 2014 Jul 29;3:e03025. doi: 10.7554/eLife.03025.PMID: 25073926 Free PMC article.
Mapping brain activity at scale with cluster computing.Freeman J, Vladimirov N, Kawashima T, Mu Y, Sofroniew NJ, Bennett DV, Rosen J, Yang CT, Looger LL, Ahrens MB.Nat Methods. 2014 Sep;11(9):941-50. doi: 10.1038/nmeth.3041. Epub 2014 Jul 27.PMID: 25068736
Light-sheet functional imaging in fictively behaving zebrafish.Vladimirov N, Mu Y, Kawashima T, Bennett DV, Yang CT, Looger LL, Keller PJ, Freeman J, Ahrens MB.Nat Methods. 2014 Sep;11(9):883-4. doi: 10.1038/nmeth.3040. Epub 2014 Jul 27.PMID: 25068735 No abstract available.
Receptive field properties of bipolar cell axon terminals in direction-selective sublaminas of the mouse retina.Chen M, Lee S, Park SJ, Looger LL, Zhou ZJ.J Neurophysiol. 2014 Oct 15;112(8):1950-62. doi: 10.1152/jn.00283.2014. Epub 2014 Jul 16.PMID: 25031256 Free PMC article.
Kainate receptors mediate signaling in both transient and sustained OFF bipolar cell pathways in mouse retina.Borghuis BG, Looger LL, Tomita S, Demb JB.J Neurosci. 2014 Apr 30;34(18):6128-39. doi: 10.1523/JNEUROSCI.4941-13.2014.PMID: 24790183 Free PMC article.
Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway.Haustein MD, Kracun S, Lu XH, Shih T, Jackson-Weaver O, Tong X, Xu J, Yang XW, O’Dell TJ, Marvin JS, Ellisman MH, Bushong EA, Looger LL, Khakh BS.Neuron. 2014 Apr 16;82(2):413-29. doi: 10.1016/j.neuron.2014.02.041.PMID: 24742463 Free PMC article.
Excitatory synaptic inputs to mouse on-off direction-selective retinal ganglion cells lack direction tuning.Park SJ, Kim IJ, Looger LL, Demb JB, Borghuis BG.J Neurosci. 2014 Mar 12;34(11):3976-81. doi: 10.1523/JNEUROSCI.5017-13.2014.PMID: 24623775 Free PMC article.
Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM.Maiti AK, Kim-Howard X, Motghare P, Pradhan V, Chua KH, Sun C, Arango-Guerrero MT, Ghosh K, Niewold TB, Harley JB, Anaya JM, Looger LL, Nath SK.Hum Mol Genet. 2014 Aug 1;23(15):4161-76. doi: 10.1093/hmg/ddu106. Epub 2014 Mar 7.PMID: 24608226 Free PMC article.
Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations.Kim-Howard X, Sun C, Molineros JE, Maiti AK, Chandru H, Adler A, Wiley GB, Kaufman KM, Kottyan L, Guthridge JM, Rasmussen A, Kelly J, Sánchez E, Raj P, Li QZ, Bang SY, Lee HS, Kim TH, Kang YM, Suh CH, Chung WT, Park YB, Choe JY, Shim SC, Lee SS, Han BG, Olsen NJ, Karp DR, Moser K, Pons-Estel BA, Wakeland EK, James JA, Harley JB, Bae SC, Gaffney PM, Alarcón-Riquelme M; GENLES, Looger LL, Nath SK.Hum Mol Genet. 2014 Mar 15;23(6):1656-68. doi: 10.1093/hmg/ddt532. Epub 2013 Oct 26.PMID: 24163247 Free PMC article.
A neuron-based screening platform for optimizing genetically-encoded calcium indicators.Wardill TJ, Chen TW, Schreiter ER, Hasseman JP, Tsegaye G, Fosque BF, Behnam R, Shields BC, Ramirez M, Kimmel BE, Kerr RA, Jayaraman V, Looger LL, Svoboda K, Kim DS.PLoS One. 2013 Oct 14;8(10):e77728. doi: 10.1371/journal.pone.0077728. eCollection 2013.PMID: 24155972 Free PMC article.
Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination.Munger SC, Natarajan A, Looger LL, Ohler U, Capel B.PLoS Genet. 2013;9(7):e1003630. doi: 10.1371/journal.pgen.1003630. Epub 2013 Jul 11.PMID: 23874228 Free PMC article.
Ultrasensitive fluorescent proteins for imaging neuronal activity.Chen TW, Wardill TJ, Sun Y, Pulver SR, Renninger SL, Baohan A, Schreiter ER, Kerr RA, Orger MB, Jayaraman V, Looger LL, Svoboda K, Kim DS.Nature. 2013 Jul 18;499(7458):295-300. doi: 10.1038/nature12354.PMID: 23868258 Free PMC article.
Two-photon imaging of nonlinear glutamate release dynamics at bipolar cell synapses in the mouse retina.Borghuis BG, Marvin JS, Looger LL, Demb JB.J Neurosci. 2013 Jul 3;33(27):10972-85. doi: 10.1523/JNEUROSCI.1241-13.2013.PMID: 23825403 Free PMC article.
β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons.Taschenberger G, Toloe J, Tereshchenko J, Akerboom J, Wales P, Benz R, Becker S, Outeiro TF, Looger LL, Bähr M, Zweckstetter M, Kügler S.Ann Neurol. 2013 Jul;74(1):109-18. doi: 10.1002/ana.23905. Epub 2013 Aug 6.PMID: 23536356
Nanotools for neuroscience and brain activity mapping.Alivisatos AP, Andrews AM, Boyden ES, Chun M, Church GM, Deisseroth K, Donoghue JP, Fraser SE, Lippincott-Schwartz J, Looger LL, Masmanidis S, McEuen PL, Nurmikko AV, Park H, Peterka DS, Reid C, Roukes ML, Scherer A, Schnitzer M, Sejnowski TJ, Shepard KL, Tsao D, Turrigiano G, Weiss PS, Xu C, Yuste R, Zhuang X.ACS Nano. 2013 Mar 26;7(3):1850-66. doi: 10.1021/nn4012847. Epub 2013 Mar 20.PMID: 23514423 Free PMC article. Review.
The Author File: Loren L. Looger. Interview by Vivien Marx.Looger LL.Nat Methods. 2013 Feb;10(2):93.PMID: 23479797 No abstract available.
Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics.Akerboom J, Carreras Calderón N, Tian L, Wabnig S, Prigge M, Tolö J, Gordus A, Orger MB, Severi KE, Macklin JJ, Patel R, Pulver SR, Wardill TJ, Fischer E, Schüler C, Chen TW, Sarkisyan KS, Marvin JS, Bargmann CI, Kim DS, Kügler S, Lagnado L, Hegemann P, Gottschalk A, Schreiter ER, Looger LL.Front Mol Neurosci. 2013 Mar 4;6:2. doi: 10.3389/fnmol.2013.00002. eCollection 2013.PMID: 23459413 Free PMC article.
Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production.Molineros JE, Maiti AK, Sun C, Looger LL, Han S, Kim-Howard X, Glenn S, Adler A, Kelly JA, Niewold TB, Gilkeson GS, Brown EE, Alarcón GS, Edberg JC, Petri M, Ramsey-Goldman R, Reveille JD, Vilá LM, Freedman BI, Tsao BP, Criswell LA, Jacob CO, Moore JH, Vyse TJ, Langefeld CL, Guthridge JM, Gaffney PM, Moser KL, Scofield RH, Alarcón-Riquelme ME; BIOLUPUS Network, Williams SM, Merrill JT, James JA, Kaufman KM, Kimberly RP, Harley JB, Nath SK.PLoS Genet. 2013;9(2):e1003222. doi: 10.1371/journal.pgen.1003222. Epub 2013 Feb 18.PMID: 23441136 Free PMC article.
An optimized fluorescent probe for visualizing glutamate neurotransmission.Marvin JS, Borghuis BG, Tian L, Cichon J, Harnett MT, Akerboom J, Gordus A, Renninger SL, Chen TW, Bargmann CI, Orger MB, Schreiter ER, Demb JB, Gan WB, Hires SA, Looger LL.Nat Methods. 2013 Feb;10(2):162-70. doi: 10.1038/nmeth.2333. Epub 2013 Jan 13.PMID: 23314171 Free PMC article.
Genetically encoded calcium indicators and astrocyte calcium microdomains.Tong X, Shigetomi E, Looger LL, Khakh BS.Neuroscientist. 2013 Jun;19(3):274-91. doi: 10.1177/1073858412468794. Epub 2012 Dec 20.PMID: 23264008
Imaging neural activity using Thy1-GCaMP transgenic mice.Chen Q, Cichon J, Wang W, Qiu L, Lee SJ, Campbell NR, Destefino N, Goard MJ, Fu Z, Yasuda R, Looger LL, Arenkiel BR, Gan WB, Feng G.Neuron. 2012 Oct 18;76(2):297-308. doi: 10.1016/j.neuron.2012.07.011. Epub 2012 Oct 17.PMID: 23083733 Free PMC article.
Optimization of a GCaMP calcium indicator for neural activity imaging.Akerboom J, Chen TW, Wardill TJ, Tian L, Marvin JS, Mutlu S, Calderón NC, Esposti F, Borghuis BG, Sun XR, Gordus A, Orger MB, Portugues R, Engert F, Macklin JJ, Filosa A, Aggarwal A, Kerr RA, Takagi R, Kracun S, Shigetomi E, Khakh BS, Baier H, Lagnado L, Wang SS, Bargmann CI, Kimmel BE, Jayaraman V, Svoboda K, Kim DS, Schreiter ER, Looger LL.J Neurosci. 2012 Oct 3;32(40):13819-40. doi: 10.1523/JNEUROSCI.2601-12.2012.PMID: 23035093 Free PMC article.
Activity in motor-sensory projections reveals distributed coding in somatosensation.Petreanu L, Gutnisky DA, Huber D, Xu NL, O’Connor DH, Tian L, Looger L, Svoboda K.Nature. 2012 Sep 13;489(7415):299-303. doi: 10.1038/nature11321.PMID: 22922646 Free PMC article.
Imaging neuronal activity with genetically encoded calcium indicators.Tian L, Hires SA, Looger LL.Cold Spring Harb Protoc. 2012 Jun 1;2012(6):647-56. doi: 10.1101/pdb.top069609.PMID: 22661439 Review.
Optogenetic analysis of a nociceptor neuron and network reveals ion channels acting downstream of primary sensors.Husson SJ, Costa WS, Wabnig S, Stirman JN, Watson JD, Spencer WC, Akerboom J, Looger LL, Treinin M, Miller DM 3rd, Lu H, Gottschalk A.Curr Biol. 2012 May 8;22(9):743-52. doi: 10.1016/j.cub.2012.02.066. Epub 2012 Apr 5.PMID: 22483941 Free PMC article.
Selective esterase-ester pair for targeting small molecules with cellular specificity.Tian L, Yang Y, Wysocki LM, Arnold AC, Hu A, Ravichandran B, Sternson SM, Looger LL, Lavis LD.Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4756-61. doi: 10.1073/pnas.1111943109. Epub 2012 Mar 12.PMID: 22411832 Free PMC article.
Excitation spectra and brightness optimization of two-photon excited probes.Mütze J, Iyer V, Macklin JJ, Colonell J, Karsh B, Petrášek Z, Schwille P, Looger LL, Lavis LD, Harris TD.Biophys J. 2012 Feb 22;102(4):934-44. doi: 10.1016/j.bpj.2011.12.056. Epub 2012 Feb 21.PMID: 22385865 Free PMC article.
A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo.Zariwala HA, Borghuis BG, Hoogland TM, Madisen L, Tian L, De Zeeuw CI, Zeng H, Looger LL, Svoboda K, Chen TW.J Neurosci. 2012 Feb 29;32(9):3131-41. doi: 10.1523/JNEUROSCI.4469-11.2012.PMID: 22378886 Free PMC article.
Neural activity imaging with genetically encoded calcium indicators.Tian L, Akerboom J, Schreiter ER, Looger LL.Prog Brain Res. 2012;196:79-94. doi: 10.1016/B978-0-444-59426-6.00005-7.PMID: 22341322 Review.
Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses.Lou X, Fan F, Messa M, Raimondi A, Wu Y, Looger LL, Ferguson SM, De Camilli P.Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):E515-23. doi: 10.1073/pnas.1121626109. Epub 2012 Jan 30.PMID: 22308498 Free PMC article.
Running in reverse: rhodopsins sense voltage.Looger LL.Nat Methods. 2011 Dec 28;9(1):43-4. doi: 10.1038/nmeth.1817.PMID: 22205516 No abstract available.
Genetically encoded neural activity indicators.Looger LL, Griesbeck O.Curr Opin Neurobiol. 2012 Feb;22(1):18-23. doi: 10.1016/j.conb.2011.10.024. Epub 2011 Nov 19.PMID: 22104761 Review.
Structure of the Escherichia coli phosphonate binding protein PhnD and rationally optimized phosphonate biosensors.Alicea I, Marvin JS, Miklos AE, Ellington AD, Looger LL, Schreiter ER.J Mol Biol. 2011 Dec 2;414(3):356-69. doi: 10.1016/j.jmb.2011.09.047. Epub 2011 Oct 12.PMID: 22019591 Free PMC article.
A genetically encoded, high-signal-to-noise maltose sensor.Marvin JS, Schreiter ER, Echevarría IM, Looger LL.Proteins. 2011 Nov;79(11):3025-36. doi: 10.1002/prot.23118.PMID: 21989929 Free PMC article.
Chemical and genetic engineering of selective ion channel-ligand interactions.Magnus CJ, Lee PH, Atasoy D, Su HH, Looger LL, Sternson SM.Science. 2011 Sep 2;333(6047):1292-6. doi: 10.1126/science.1206606.PMID: 21885782 Free PMC article.
Two-photon calcium imaging of evoked activity from L5 somatosensory neurons in vivo.Mittmann W, Wallace DJ, Czubayko U, Herb JT, Schaefer AT, Looger LL, Denk W, Kerr JN.Nat Neurosci. 2011 Jul 10;14(8):1089-93. doi: 10.1038/nn.2879.PMID: 21743473
Imaging light responses of targeted neuron populations in the rodent retina.Borghuis BG, Tian L, Xu Y, Nikonov SS, Vardi N, Zemelman BV, Looger LL.J Neurosci. 2011 Feb 23;31(8):2855-67. doi: 10.1523/JNEUROSCI.6064-10.2011.PMID: 21414907 Free PMC article.
Drosophila Brainbow: a recombinase-based fluorescence labeling technique to subdivide neural expression patterns.Hampel S, Chung P, McKellar CE, Hall D, Looger LL, Simpson JH.Nat Methods. 2011 Mar;8(3):253-9. doi: 10.1038/nmeth.1566. Epub 2011 Feb 6.PMID: 21297621 Free PMC article.
A dimorphic pheromone circuit in Drosophila from sensory input to descending output.Ruta V, Datta SR, Vasconcelos ML, Freeland J, Looger LL, Axel R.Nature. 2010 Dec 2;468(7324):686-90. doi: 10.1038/nature09554.PMID: 21124455
Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall.Xiang Y, Yuan Q, Vogt N, Looger LL, Jan LY, Jan YN.Nature. 2010 Dec 16;468(7326):921-6. doi: 10.1038/nature09576. Epub 2010 Nov 10.PMID: 21068723 Free PMC article.
Filtering of visual information in the tectum by an identified neural circuit.Del Bene F, Wyart C, Robles E, Tran A, Looger L, Scott EK, Isacoff EY, Baier H.Science. 2010 Oct 29;330(6004):669-73. doi: 10.1126/science.1192949.PMID: 21030657 Free PMC article.
Functional imaging of hippocampal place cells at cellular resolution during virtual navigation.Dombeck DA, Harvey CD, Tian L, Looger LL, Tank DW.Nat Neurosci. 2010 Nov;13(11):1433-40. doi: 10.1038/nn.2648. Epub 2010 Oct 3.PMID: 20890294 Free PMC article.
The role of the TRP channel NompC in Drosophila larval and adult locomotion.Cheng LE, Song W, Looger LL, Jan LY, Jan YN.Neuron. 2010 Aug 12;67(3):373-80. doi: 10.1016/j.neuron.2010.07.004.PMID: 20696376 Free PMC article.
Near-isotropic 3D optical nanoscopy with photon-limited chromophores.Tang J, Akerboom J, Vaziri A, Looger LL, Shank CV.Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10068-73. doi: 10.1073/pnas.1004899107. Epub 2010 May 14.PMID: 20472826 Free PMC article.
Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators.Tian L, Hires SA, Mao T, Huber D, Chiappe ME, Chalasani SH, Petreanu L, Akerboom J, McKinney SA, Schreiter ER, Bargmann CI, Jayaraman V, Svoboda K, Looger LL.Nat Methods. 2009 Dec;6(12):875-81. doi: 10.1038/nmeth.1398. Epub 2009 Nov 8.PMID: 19898485 Free PMC article.
Enzyme stabilization by domain insertion into a thermophilic protein.Kim CS, Pierre B, Ostermeier M, Looger LL, Kim JR.Protein Eng Des Sel. 2009 Oct;22(10):615-23. doi: 10.1093/protein/gzp044. Epub 2009 Jul 21.PMID: 19622545
A bright and photostable photoconvertible fluorescent protein.McKinney SA, Murphy CS, Hazelwood KL, Davidson MW, Looger LL.Nat Methods. 2009 Feb;6(2):131-3. doi: 10.1038/nmeth.1296. Epub 2009 Jan 25.PMID: 19169260 Free PMC article.
Crystal structures of the GCaMP calcium sensor reveal the mechanism of fluorescence signal change and aid rational design.Akerboom J, Rivera JD, Guilbe MM, Malavé EC, Hernandez HH, Tian L, Hires SA, Marvin JS, Looger LL, Schreiter ER.J Biol Chem. 2009 Mar 6;284(10):6455-64. doi: 10.1074/jbc.M807657200. Epub 2008 Dec 18.PMID: 19098007 Free PMC article.
Reporting neural activity with genetically encoded calcium indicators.Hires SA, Tian L, Looger LL.Brain Cell Biol. 2008 Aug;36(1-4):69-86. doi: 10.1007/s11068-008-9029-4. Epub 2008 Oct 22.PMID: 18941901 Free PMC article. Review.
Crystallization and preliminary X-ray characterization of the genetically encoded fluorescent calcium indicator protein GCaMP2.Rodríguez Guilbe MM, Alfaro Malavé EC, Akerboom J, Marvin JS, Looger LL, Schreiter ER.Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 1;64(Pt 7):629-31. doi: 10.1107/S1744309108016059. Epub 2008 Jun 11.PMID: 18607093 Free PMC article.
Fluorescence resonance energy transfer sensors for quantitative monitoring of pentose and disaccharide accumulation in bacteria.Kaper T, Lager I, Looger LL, Chermak D, Frommer WB.Biotechnol Biofuels. 2008 Jun 3;1(1):11. doi: 10.1186/1754-6834-1-11.PMID: 18522753 Free PMC article.
Retraction.Dwyer MA, Looger LL, Hellinga HW.Science. 2008 Feb 1;319(5863):569. doi: 10.1126/science.319.5863.569b.PMID: 18239106 No abstract available.
Genetically encoded fluorescent sensors for studying healthy and diseased nervous systems.Tian L, Looger LL.Drug Discov Today Dis Models. 2008;5(1):27-35. doi: 10.1016/j.ddmod.2008.07.003.PMID: 19461949 Free PMC article.
Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle.Kaper T, Looger LL, Takanaga H, Platten M, Steinman L, Frommer WB.PLoS Biol. 2007 Oct;5(10):e257. doi: 10.1371/journal.pbio.0050257.PMID: 17896864 Free PMC article.
A metalloantibody that irreversibly binds a protein antigen.Trisler K, Looger LL, Sharma V, Baker M, Benson DE, Trauger S, Schultz PG, Smider VV.J Biol Chem. 2007 Sep 7;282(36):26344-53. doi: 10.1074/jbc.M704675200. Epub 2007 Jul 6.PMID: 17617633
A novel analytical method for in vivo phosphate tracking.Gu H, Lalonde S, Okumoto S, Looger LL, Scharff-Poulsen AM, Grossman AR, Kossmann J, Jakobsen I, Frommer WB.FEBS Lett. 2006 Oct 30;580(25):5885-93. doi: 10.1016/j.febslet.2006.09.048. Epub 2006 Oct 2.PMID: 17034793 Free PMC article.
Conversion of a putative Agrobacterium sugar-binding protein into a FRET sensor with high selectivity for sucrose.Lager I, Looger LL, Hilpert M, Lalonde S, Frommer WB.J Biol Chem. 2006 Oct 13;281(41):30875-83. doi: 10.1074/jbc.M605257200. Epub 2006 Aug 15.PMID: 16912038
Construction and optimization of a family of genetically encoded metabolite sensors by semirational protein engineering.Deuschle K, Okumoto S, Fehr M, Looger LL, Kozhukh L, Frommer WB.Protein Sci. 2005 Sep;14(9):2304-14. doi: 10.1110/ps.051508105.PMID: 16131659 Free PMC article.
Genetically encoded FRET sensors for visualizing metabolites with subcellular resolution in living cells.Looger LL, Lalonde S, Frommer WB.Plant Physiol. 2005 Jun;138(2):555-7. doi: 10.1104/pp.104.900151.PMID: 15955913 Free PMC article. No abstract available.
Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors.Okumoto S, Looger LL, Micheva KD, Reimer RJ, Smith SJ, Frommer WB.Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8740-5. doi: 10.1073/pnas.0503274102. Epub 2005 Jun 6.PMID: 15939876 Free PMC article.
Genetically encoded sensors for metabolites.Deuschle K, Fehr M, Hilpert M, Lager I, Lalonde S, Looger LL, Okumoto S, Persson J, Schmidt A, Frommer WB.Cytometry A. 2005 Mar;64(1):3-9. doi: 10.1002/cyto.a.20119.PMID: 15688353 Free PMC article. Review.
Analysis of allosteric signal transduction mechanisms in an engineered fluorescent maltose biosensor.Dattelbaum JD, Looger LL, Benson DE, Sali KM, Thompson RB, Hellinga HW.Protein Sci. 2005 Feb;14(2):284-91. doi: 10.1110/ps.041146005.PMID: 15659363 Free PMC article.
Computational design of receptors for an organophosphate surrogate of the nerve agent soman.Allert M, Rizk SS, Looger LL, Hellinga HW.Proc Natl Acad Sci U S A. 2004 May 25;101(21):7907-12. doi: 10.1073/pnas.0401309101. Epub 2004 May 17.PMID: 15148405 Free PMC article.
Computational design of receptor and sensor proteins with novel functions.Looger LL, Dwyer MA, Smith JJ, Hellinga HW.Nature. 2003 May 8;423(6936):185-90. doi: 10.1038/nature01556.PMID: 12736688
Control of a biomolecular motor-powered nanodevice with an engineered chemical switch.Liu H, Schmidt JJ, Bachand GD, Rizk SS, Looger LL, Hellinga HW, Montemagno CD.Nat Mater. 2002 Nov;1(3):173-7. doi: 10.1038/nmat761.PMID: 12618806
Construction of a fluorescent biosensor family.de Lorimier RM, Smith JJ, Dwyer MA, Looger LL, Sali KM, Paavola CD, Rizk SS, Sadigov S, Conrad DW, Loew L, Hellinga HW.Protein Sci. 2002 Nov;11(11):2655-75. doi: 10.1110/ps.021860.PMID: 12381848 Free PMC article.